Molecular Human Targets of Bioactive Alkaloid-Type Compounds from Tabernaemontana cymose Jacq.

Monogagaine, a Novel Dimeric Indole Alkaloid from Tabernaemontana chippii and Tabernaemontana dichotoma [1]

Tabernaemontana chippii and Tabernaemontana dichotoma [1] Teris A. van Beek*, Peter P. Lankhorst, Robert Verpoorte, Georges Massiot, Roel Fokkens, Cornelis Erkelens, Premila Perera, and Cecilia Tibell a Department of Pharmacognosy, Gorlaeus Laboratories, P .O.Box 9502, 2300 R A Leiden, The Netherlands b Depar tment of Organic Chemistry, Leiden, The Netherlands c Faculte de Pharmacie, Reims, Fra...

A New Indole Alkaloid Isolated from Tabernaemontana hystrix Steud (Apocynaceae)

Um novo alcalóide, denominado histrixnina (1), e cinco alcalóides indólicos conhecidos, ibogamina (2), olivacina (3) e affinina (4), affinisina (5) e N b -metilaffinisina (6), foram isolados do extrato metanólico das cascas das raízes de Tabernaemontana hystrix. Os triterpenos conhecidos 3O-acetil-α-amirina, 3-O-acetil-β-amirina, 3-O-acetil-lupeol foram também identificados. As estruturas dos c...

Bioactive Compounds from the Marine Sponge Geodia barretti Characterization, Antifouling Activity and Molecular Targets

Polycyclic indole alkaloid-type compounds by MCR.

Polycyclic indole moieties are often part of bioactive natural or synthetic products, however traditionally have to be synthesized over several steps involving time consuming sequential multi-step syntheses. We herein communicate an efficient and flexible 2-step procedure to complex multicyclic indole alkaloid-type compounds involving Ugi MCR and Pictet-Spengler reaction.

Molecular Approaches to Screen Bioactive Compounds from Endophytic Fungi

Endophytic fungi are capable of producing plant associated metabolites and their analogs with therapeutic value. In order to identify the potential endophytic isolates producing bioactive compounds, one need to screen all isolated endophytes, which may run into hundreds. Isolation of endophytic fungi is relatively a simple process; but screening of the isolated fungi for required metabolite pro...